The Effect of Pharmaceutical Analgesics on Renal Failure Using Novel Nano-Composite Drugs
DOI:
https://doi.org/10.59675/V314Keywords:
Naproxen drug, Naproxen drug nanocomposite polymer, Molecular docking, Biochemical parameters, Renal failure.Abstract
Naproxen drug–polymer nanocomposite was prepared by condensation polymerisation, as reported in the medical literature. The molecular docking of the nanocomposite drug with amino acids within the 1UPT protein inside kidney cancer cells was studied.
Biochemical changes were studied by measuring the level of urea in the blood serum according to the method mentioned in the kit, and the level of creatinine was also measured according to the method mentioned in the kit. Biochemical changes were studied by taking 15 male white rats, whose average age ranged between 11 and 12 weeks and whose weight ranged between 120 and 150 grams. They were placed under appropriate conditions in terms of temperature, the lighting period was 12 hours a day, and they were well ventilated. They fed special fodder, and they were provided with water. The white rats used in the experiment were randomly divided into three groups. The first group was given sodium chloride as a physiological saline solution orally and was considered a control group. The second and third groups were dosed with Naproxen drug and the nanocomposites-Naproxen drug, respectively, at a concentration of 51 mg/kg for 14 days.
The results concluded that some of the effects of biochemical parameters on serological and pathological changes in the Kidney were obtained as a result of the use of loaded Naproxen drug on nano co-polymer.
References
Ayat HA, Alsafy AH, AL-Baiati MN. Study of the effective range of drug level using a novel nano co-polymer-mefenamic acid. Int J Drug Deliv Technol. 2022;12(4):1808-13.
Aljanabi A, et al. Modification of polyethersulfone ultrafiltration membrane using poly(terephthalic acid-co-glycerol-g-maleic anhydride) as novel pore former. Polymers. 2022;14(16):3408.
Abd Nusaif KMH, Nusaif KA, IJR. Association between sex hormonal and metabolic changes in female with infertility, in Al-Najaf city patients. GinPolMedProject. 2024;4(68):1-5.
Abdulnabi O, Alsalame H, Al-Baiati M. Studying the use of chitosan-cephalexin nano composite to induce ROS and apoptosis in colon cancer cell line HCT-29. Moroccan J Chem. 2024;12(3):1270-80.
Al-Ghanimi B, Abd Nusaif KI, Al-Baiati MN. Studying the use of a novel nano chitosan loaded with amoxicillin in the treatment of lung cancer cell line (A549). Moroccan J Chem. 2025;13(2):480-94.
Khudhair AR, Sherazi ST, Al-Baiati MN. Adsorption of methylene blue from aqueous solutions using a novel nano co-polymer. AIP Conf Proc. 2020;2290:030021.
Obaid MM, Al-Baiati MN. Studying the effectiveness of using a novel nano polymer as a protein delivery system. AIP Conf Proc. 2023;2414(1):050041.
T.H. Zeyad, Ab, Khawla I, Maryam SN, ESA. Monitoring study on the incidence of 25-OH Vitamin D deficiency in the population of Kerbala province. Egyptian J Chem. 2022;65(SI:13):1319-22.
Kaygusuz H, Uysal M, Adımcılar V, Erim FB. Natural alginate biopolymer montmorillonite clay composites for vitamin B2 delivery. J Bioactive Compat Polym. 2015;30(1):48-56.
Abd Nusaif KI, Al-Baiati MN, Abbas AH, Abed AS, Abood ES. Nano-poly chitosan-ampicillin drug: synthesis, characterization and cytotoxicity. Egyptian J Chem. 2022;65(131):1313-8.
Abbas AH, Al-Baiati MN. Use of nano-poly chitosan cephalexin drug to inhibit spread of cancer cells. Int J Drug Deliv Technol. 2023;13(1):29-32.
Bahadar H, Maqbool F, Niaz K, Abdollahi M. Toxicity of nanoparticles and an overview of current experimental models. Iran Biomed J. 2016;20(1):1-11.
Johnston HJ, Hutchison G, Christensen FM, Peters, Hankin S, Stone V. A review of the in vivo and in vitro toxicity of gold particulates, particle attributes and biological mechanisms responsible for the observed toxicity. Crit Rev Toxicol. 2010;40:328-46.
Kumar A, Vemula PK, Ajayan PM, John G. Silver-nanoparticle-embedded antimicrobial paints based on vegetable oil. Nat Mater. 2008;7:236-41.
Sung JH, Ji JH, Yoon JU, Kim DS, Song MY, Jeong J. Lung function changes in Sprague Dawley rats after prolonged inhalation exposure to nanoparticles. Inhal Toxicol. 2008;20:567-74.
Ali HA, Abd KI. Identifying the LBP and insulin resistance: potential role for the increased feto-maternal morbidity and long-term complications. Biochem Cell Arch. 2020;20(2):5781-6.
Ema M, Kobayashi N, Naya M, Hanai S, Nakanishi J. Reproductive and developmental toxicity studies of manufactured nanomaterials. Reprod Toxicol. 2010;30:343-52.
Zadeh AR, et al. Mechanism and adverse effects of multiple sclerosis drugs: a review article. Part 2. Int J Physiol Pathophysiol Pharmacol. 2019;11(4):105.
Shakir ZM, Kareem MM, Al-Baiati MN. Study the effects of some nano graft co-polymer-drugs on the spread of breast cancer. AIP Conf Proc. 2023;2414(1):050005.
Abdulridha AA, Abdul-Rida NA, AL-Baiati MN. Synthesis of novel nano co-polymer as pH sensitive drug delivery system, experimental and theoretical study. AIP Conf Proc. 2023;2414(1):050028.
Surur FH, Zeyad TH, AL-Baiati MN. Synthesis and characterization of novel nano co-polymer-drugs composites and using it as treatment for liver cancer. Moroccan J Chem. 2025;13(1):106-21.
Somchit MN, Sanat F, Hui GE, Wahab SI, Ahmad Z. Mefenamic acid induced nephrotoxicity: an animal model. Adv Pharm Bull. 2014;4(4):401.
Shrivastava A, Gupta A, Girshick R. Training region-based object detectors with online hard example mining. In Proceedings of the IEEE conference on computer vision and pattern recognition 2016 (pp. 761-769).
Ulinski T, Guigonis V, Dunan O, Bensman A. Acute renal failure after treatment with non-steroidal anti-inflammatory drugs. Eur J Pediatr. 2004;163(3):148-50.
Al-Aama ZMA, AL-Masoudi HQ, Abdulridha AA, Abd Nusaif KI, AL-Baiati MN. Synthesis of a smart nano graft co-polymer as drug delivery. AIP Conf Proc. 2023;2414(1):050030.
Whelton A, Watson AJ. Nonsteroidal anti-inflammatory drugs: effects on kidney function. In: Clinical Nephrotoxins. 1998. p. 203-16.
Puppala N, Reddy GA. Review on effects of NSAIDs on different systems. Asian J Pharm Res Dev. 2020;8(1):100-9.
Cunningham K, Candelario DM, Angelo LB. Nonsteroidal anti-inflammatory drugs: updates on dosage formulations and adverse effects. Orthop Nurs. 2020;39(6):408-13.
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