Synergistic Effectiveness of Crude Extract Leaves of Moringa Oleifera Lam and Atorvastatin-Treated Rabbits
DOI:
https://doi.org/10.59675/V311Keywords:
Cholesterol; Atorvastatin; Moringa oleifera Lam, Liver enzymes, Kidney function test, Antioxidant.Abstract
Moringa oleifera supplementation may help regulate hypercholesterolemic conditions in rabbits treated with atorvastatin, according to the data, which showed that the novel nutraceutical combination had a substantial influence on cholesterol metabolism. The purpose of this study was to examine the potential synergistic effects of Moringa oleifera in rabbits receiving atorvastatin treatment, which is commonly used to decrease cholesterol. Following a 28-day period of 1% cholesterol in rabbits, we gave them oral atorvastatin 50 gm/kg and/or Moringa oleifera Lam 200 mg/kg/day. In comparison to the corresponding control groups, the results demonstrated that dietary supplementation with Moringa oleifera Lam and atorvastatin significantly decreased blood levels of cholesterol and oxidant (MDA), liver enzymes (AST and ALT), and certain kidney function tests (urea, creatinine), while upregulating antioxidants. Our goal was to find out how the extraction of Moringa oleifera Lam demonstrated the plant's synergistic efficacy and provided a potentially useful therapeutic strategy that might be used with atorvastatin therapy.
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