Experimental Study of Chitosan for Skin Wounds Healing in Rats
DOI:
https://doi.org/10.59675/V121Keywords:
Wound Healing; Rat; Chitin; Chitosan.Abstract
The present investigation's objective was to evaluate how Chitosan affected the healing of rats' full-thickness cutaneous wounds. All animals were generated with a clinically healthy (2 cm2) full-thickness dorsal back wound in 24 male adult rats (200- 250 g). Under the influence of a combination of 1 mg/kg of Acepromazine, 75 mg/kg of ketamine hydrochloride, and 10 mg/kg of xylazine hydrochloride. These animals were separated into three groups (A, B, and C) based on the treatment plan. The wounds in group (A) were treated locally with chitosan wound powder, whereas group (B) applied chitosan wound powder both locally and orally to treat the wounds, and group (C) left the wounds untreated as a control group. On 0, 3, 7, and 14 days after wound creation and treatment, four subgroups were formed for each group, having two wounds in each subgroup. Clinically, the result showed that wounds in group B healed faster than wounds in group A and group C. In addition, the results revealed that group (B) have enhanced cellularity, increased vasculature with the superiority of than those in both group (A) and group (C). Conclusion; The study show that the Chitosan work on increase wound healing and decrease Edam formation in the wound and replace the damaged part of the skin.
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